What the new research shows
The Bredesen Protocol for the prevention and
treatment of Alzheimer’s disease derives its success from its core
concept. That concept is that the
disease is driven by the coalescence of multiple metabolic imbalances that are
driven by lifestyle factors such as diet, exercise, sleep, stress and
others.
A growing body of research has been showing that these
factors such as chronic low omega-3 fatty acid intake or low blood vitamin B12
levels impair brain health and cognitive function. However, preventing or correcting these
factors individually has been shown to impart only small preventative/protective effects which help but are not enough to make large
impacts on the disease. The core concept
of the Bredesen Protocol assumes that finding all of the collective factors
that are involved and correcting all of them simultaneously will yield much
broader results.
To date about 40 factors have been identified and are
investigated in the protocol. Any given
individual may have 21 factors that are imbalanced, and a specific treatment
program will target that pattern. The
next individual may have 30 different factors that are imbalanced and their
specific treatment program will be targeted to those. It is this comprehensiveness and individually
specific design of each treatment program that has resulted in the excellent
treatment outcomes. The whole really has
proven greater than simply the sum of the parts.
I thought it would be good to look at some the latest
research examining some of these factors that relate to the risk of developing
the disease.
The Inflammatory US Diet and Dementia/Alzheimer’s Disease
Chronic
inflammation is a potent risk factor for the developments and progression of
Alzheimer’s disease. Lifestyle factors
that contribute to chronic inflammation are therefore therapeutic targets in
treatment. One of those lifestyle
factors that has been shown to contribute to chronic inflammation is diet.
A new study
looked at the relationship between dietary patterns known to be associated with
chronic inflammation and the risk of developing pre-Alzheimer’s (MCI) or
dementia. Compared to those chronically
eating the anti-inflammatory Mediterreanean dietary pattern, those consuming
the standard American diet which is considered pro-inflammatory had a 27%
increased risk. The results led the
researchers to conclude: “Diets with the highest pro-inflammatory potential
were associated with higher risk of MCI or dementia.”
Diet is
perhaps the single lifestyle factor most associated with broad chronic disease
risks.
Hayden et al. The association between an inflammatory diet
and global cognitive function and incident dementia in older women: The Women's
Health Initiative Memory Study.
Alzheimers & Dementia, ePub 2017.
The Importance of Cognitive Reserves
In a previous
post I discussed the impact of cognitive reserve of
the risk of Alzheimer’s disease. Simply
put, the more exercise and development the brain has had during life the more
resistant it is to developing the disease with age. This study looked at risk associated with low
cognitive development and reserves.
During a 44
year follow-up each standard deviation of decreased cognitive ability was
associated with increased risk of dementia of 33%. In this type of analysis they take the
average cognitive ability across a large group and compare those with moderate
(1 standard deviation) and substantial (2 standard deviations) lower from this
average.
The key
point here is that the brain needs exercise throughout life and the greater the
“strength” it has, the more resistant it is to developing Alzheimer’s. Although not looked at in this study, other
study has shown that cognitive exercise even in later life has preventative and
therapeutic benefit.
Osler et al. Cognitive ability in young adulthood and risk
of dementia in a cohort of Danish men, brothers, and twins. Alzheimers & Dementia, ePub 2017.
The Impact of Low Vitamin D Levels on Cognitive Decline
One of the
important variables in the Bredesen Protocol which is measured and closely
managed is the blood vitamin D levels. A
new study looked at this variable in older subjects to see if it correlated
with the rate of cognitive decline and the risk of transitioning to Alzheimer’s
or some other form of dementia.
Compared to
individuals with normal vitamin D levels participants with vitamin D deficiency
exhibited a faster cognitive decline over the study period. A total of 177
dementia cases, including 124 cases of Alzheimer’s disease occurred. Those with vitamin D deficiency had a nearly
three-fold increased risk of Alzheimer’s disease.
The normal
lab range for blood vitamin D is 32-100 mg/dL.
Research has found that the ideal level for the prevention of chronic
disease is 50 mg/dL. This suggests that
many individuals assuming that their levels are adequate are actually at
greater risk.
Feart et al. Associations of lower vitamin D concentrations
with cognitive decline and long-term risk of dementia and Alzheimer's disease
in older adults. Alzheimers &
Dementia, ePub 2017.
Exercise and Beta Amyloid Accumulation
The primary
toxic protein that causes the brain cell loss in Alzheimer’s disease is called
beta amyloid. While the brain is always
making some of this protein, it only becomes toxic when it builds up in higher
amounts in the brain tissue. There are
many factors that cause the brain to produce too much beta amyloid exceeding
the ability to remove it. Inflammation
is a key example. There are other
factors that affect beta amyloid removal such as low omega-3 fatty acid intake
which also increases the likelihood of build-up.
Exercise
seems to be another variable that influences the risk of beta amyloid
build-up. A new study examined the
presence of beta amyloid build-up with PET scans using a tracer that highlights
this protein. In those without positive PET
scans there were equal numbers of high and low-level exercisers. However, when they separated out those
subjects already showing some beta amyloid build-up, it was significantly
higher in those who had low exercise levels. This suggests that when there are
other factors driving beta amyloid build-up in the brain, higher levels of
regular exercise seems to prevent this from progressing.
This
observation is supported by other research that has found regular exercise to be
therapeutically helpful in preventing progression in pre-Alzheimer’s patients.
Brown et at al. Habitual exercise levels are associated with
cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease. Alzheimers & Dementia, ePub 2017.
Mineral Deficiencies and Alzheimer’s
Risk
The body
uses two classes of antioxidants, endogenous (made within the body) and
exogenous (supplied from diet). The
endogenous antioxidants are also dietary dependent as they require dietary
factors such as minerals. Selenium is needed to produce the body’s major endogenous
antioxidants such as glutathione.
As oxidative
stress which is not effectively neutralized by antioxidants is a primary
mechanism that drives brain degeneration in Alzheimer’s and dementia, selenium
status is of concern. Most of human
selenium intake comes from plant based foods and those levels are determined by
the selenium content of the soil they are grown in.
Given the
above facts a study was set up to examine the relationship between selenium
levels in different geographic locations and Alzheimer’s risk. The risk of the disease in the 6 states with
the lowest selenium content was increased 53% compared to the 6 states with the
highest levels.
The
conclusion is simple. Inadequate supply
of dietary nutrients that are used in the inherent antioxidant systems is a
strong risk factor for Alzheimer’s disease.
Sun H. Associations of Spatial Disparities of
Alzheimer's Disease Mortality Rates and Soil Selenium, Sulfur Concentrations,
and Risk Factors in the United States.
J Alzheimers Dis. ePub 2017.
Too Few Good Fats or Too much Bad Fat Highly Associated with
Alzheimer’s Risk
apoE4
genotype causes decreased transport of needed long chain fatty acids such as
omega-3s that cell membranes need for growth of neurons to keep up with
establishing new synaptic connections. The
presence of the apoE4, which is the major genetic risk factor for
Alzheimer’s disease, may require higher daily intake of omega-3 fatty acids to
achieve adequate cell membrane levels that are associated with disease
protection.
The above
issue is why a cell omega-3 fatty acid test should be used to determine cell
membrane levels rather than simply using a certain dietary level particularly
in the 15% (1 in 6 adults) of the population with the apoE4 gene variant.
Intake of trans-FAs
(hydrogenated oils and fats in processed food) of 4.8g/day showed a 5-fold
higher relative risk to develop Alzheimer’s than subjects consuming
1.8g/day.
Grimm et al. Omega-3 fatty acids, lipids and apoE
lipidation in Alzheimer’s disease: a rationale for multi-nutrient dementia
prevention. Journal of Lipid
Research, ePub 2017.
Summary
The research
continues to expand on the risk of Alzheimer’s disease with modifiable
lifestyle factors such as diet and nutrient intake. While many factors are shown to have a
relationship to risk and their correction can be beneficial, no one factor
alone will generate a striking reduction.
However, when large groups of these factors are all examined and managed
together, the results can be striking as Dr. Bredesen has demonstrated.
The whole really has proven greater than simply the sum of the parts.
Banks Nutrition Center
We are proud
to be a certified Bredesen Protocol provider.
We are available to help anyone who is concerned about their risk of
developing the disease or those who have begun to notice cognitive difficulty.
The Bredesen
Protocol
Preventing
& Treating Alzheimer’s Disease
Dr. Scott Banks, D.C., M.S. - Clinical Nutritionist
Event Date: Saturday, June 10th 2017
Time: 11:00AM to 1:00PM
Banks Nutrition Center
Location: 200 Golden Oak Court, Suite 100
Reflections ll Building
Virginia Beach VA 23452
Office Phone Number: 757-456-5053
This is a free educational event to the public & seating
is limited.
If you would like to join us, please call our office to
reserve your seat.
Alzheimer's illness is common in my family, I have been stressed at work for at least 16 years suffered depression my thoughts were blocked. So I knew the need to keep a watch on it, that was when I began to walk several times a week, 2 miles a day and realized that was a positive thing, but it got to a point my whole body started getting weaker, I needed some help. I started up training, the trainer came to my hometown 5 times a week and he told me that would be able to help me. I agreed with him and was happy I finally found solution not until I woke up one day and couldn't walk. Tried out so many medications and diet but none of them was able to help me. In the process I knew about ZOMO, an herbal medicine for Alzheimer's disease, I followed the blog address shared; I curiously contacted him and got ZOMO. I didn’t want to be disabled at my old age, and was so hungry for more healthy days on earth. My recovery involved both medicine and diet. I never had any complications I experienced while on English medications why using ZOMO. You may contact Dr. Charanjit via his email. charantova@gmail.com or visit his blog via curetoalzheimer.blogspot.com
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ReplyDeleteI’m here to testify about what Dr James did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 4 years and had constant pain and itching, especially in my private part. During the first year.This disease started circulating all over my body and I have used Oregano oil, Coconut oil, Acyclovir, Valacyclovir, Famciclovir, and some other products and it really helped during my outbreaks but I totally got cured! from my HSV with a strong and active herbal medicine ordered from Dr James herbal mix and it completely fought the virus from my nervous system and I was tested negative after 15 days of using Dr James herbal mix medicine. I'm here to let y'all know that herpes virus has a complete cure, I got rid of mine with the help of Dr James herbal medicine. I came across a testimony of Kasha, on the internet testifying about Dr James , on how he cured Her from 7 years HSV 2. And she also gave the email address of Dr James... [drjamesherbalmix@gmail.com]..., advising anybody to contact him for help on any kind of diseases that he would be of help with, so I emailed him telling him about my (HSV 2) he told me not to worry that I'm going to be cured!! Well, I never doubted him. I have faith he can cure me too,, Dr James prepared and sent me his herbal mix medicine made of roots and herbs which I took. In the first one week, I started experiencing changes all over me, after 15 days I drank his herbal mix medicine, I was totally cured. no more itching , pain on me anymore as Dr James assured me. After some time I went to my doctor to do another test. the result came out negative. So friends my advice is if you have such disease or know anyone who suffers from it or any other disease like Alzheimer's Disease, Warts,Moles, Bipolar disorder, Shingles, HPV, HBV, HIV/AIDS, ALS, HBP, CANCER,NEPHROTIC SYNDROME HIV / AIDS, herpes cancer,Ovarian Cancer,Pancreatic cancers, bladder cancer, bladder cancer, prostate cancer, Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Autism,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,psoriasis ,Tach Diseases,Lupus,Backache,dementia.kidney cancer, lung cancer, skin cancer, skin cancer and skin cancer.testicular Cancer, , LEUKEMIA, VIRUSES, HEPATITIS, INFERTILITY . , etc. you can contact Dr James directly on his.... [drjamesherbalmix@gamil.com]... He is a good man,and He will help you.
ReplyDeleteI can’t forget in a hurry my Mom's horrible years of fight with Mental ailment (Alzheimer). My Mom got really sick around Christmas that year. When I saw her in the hospital with all those tubes, I just lost it. I got so hysterical that I had to be escorted out. Soon after that, I got into that altercation with my neighbor and was sent to jail. When I got out of jail, Her symptoms were acting up and I felt so angry. Dad had already taken her to a state psychiatric hospital. I was really nervous, but I talked to a psychiatrist there who made me feel comfortable. For the first time, she opened up about what she was experiencing—the voices, not being able to remember things, the paranoia. She said, “Your mom is battling Alzheimer.” I didn’t even know what that meant.
ReplyDeleteHe suggested that when she got out of the hospital and off the treatments she was taking there, we try a new treatment for Alzheimer. After weighing the risks and benefits, we both agreed the treatment, given through monthly injections, might help control her symptoms. Meanwhile, I made friends, and gained insight into her illness. During the week, there were movies, cooking classes and education sessions about her disease—basically, activities to help people like her get back into society. I learned about Alzheimer and what some of her triggers were. All told, she stayed there for two months and we left, I was taking her for doctor’s appointments and grocery shopping. It was hard, especially when her birthday passed, I still helped her walk, fix her food and dress her which made me sad because she was very active at 69 until the illness struck her.
I came across a herbal medication sometimes last year called zomo but before we started the treatment, we started a day rehabilitation program, and also started the new medication with zomo. I was working hard to achieve my care goals by following the treatment plan. Her symptoms got under control within three months, as she started feeling better. First she regained interest in the things she used to enjoy, like calling/visiting our family and friends for lunch and going for walks in the park and grocery shopping. I will never forget what I went through, or what it took for her to get here. I don’t take any of it for granted. I consider myself an advocate for people who don’t have any knowledge about this herbal medicine. To anyone who’s taken the time to read this that may be struggling with this awful ailment (Alzheimer), reach out, share, I guarantee you reach out to charantova@gmail.com, and know, that as lonely as you may feel, as hopeless as you believe things are, please know, that there are so many patients out there going through same and you are never alone! reach out to him so you could share your own testimony to let others know there is hope.